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Mortality and years of potential life loss in systemic lupus erythematosus: a population-based cohort study

K Lerang1, I-M Gilboe2, D Steinar Thelle3

  • 1Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway klerang@ous-hf.no.

Lupus
|September 12, 2014
PubMed

Insights

Systemic lupus erythematosus (SLE) patients face significantly reduced survival rates and a higher risk of premature death compared to the general population. Years of Potential Life Lost (YPLL) offers valuable insights into SLE prognosis.

Area of Science:

  • Rheumatology
  • Epidemiology
  • Public Health

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with significant morbidity and mortality.
  • Assessing long-term outcomes and mortality patterns in SLE patients is crucial for understanding disease impact.

Purpose of the Study:

  • To evaluate survival, mortality rates, and causes of death in a cohort of SLE patients in Oslo.
  • To compare SLE patient mortality with the general population using Standardized Mortality Ratio (SMR) and Years of Potential Life Lost before 60 (YPLL60).

Main Methods:

  • Identification of 325 SLE patients meeting American College of Rheumatology (ACR) criteria in Oslo (1999-2009).
  • Analysis of survival (inception cohort, n=127), SMR, YPLL60, and causes of death.
  • Comparison with a matched general population control group.

Main Results:

  • Five- and 10-year survival rates were 95% and 90%, significantly lower than controls.
  • Overall SMR was 3.0, with highest rates in females aged 16-39.
  • SLE patients exhibited a 10-fold higher YPLL60 compared to controls, highlighting premature mortality.

Conclusions:

  • SLE patients experience reduced survival and increased premature mortality.
  • YPLL60 provides a valuable metric for assessing SLE prognosis, emphasizing active disease impact.
  • Mortality analysis in SLE should incorporate YPLL to supplement traditional measures.

Keywords:
Systemic lupus erythematosusepidemiologymortalityoutcomesurvival rate

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