A prospective, randomised, controlled multicentre study comparing cervical disc replacement with anterior cervical...

Area of Science:

• Spine surgery
• Orthopedic research
• Biomechanical engineering

Background:

• Anterior cervical decompression and fusion (ACDF) has drawbacks.
• Total cervical disc replacement (TDR) aims to mimic natural disc structure.
• Mobi-C disc prostheses offer a TDR option.

Purpose of the Study:

• Compare clinical and radiographic outcomes of Mobi-C TDR versus ACDF.
• Evaluate the efficacy and safety of Mobi-C artificial cervical disc replacement.
• Assess long-term functional and structural results of cervical spine procedures.

Main Methods:

• Prospective, randomized, controlled, multicenter study with 111 patients.
• Single-level Mobi-C TDR (n=55) vs. ACDF (n=56).
• Clinical outcomes (JOA, VAS, NDI) and radiographic parameters (ROM, FSU angle) assessed up to 48 months.

Main Results:

• Both Mobi-C and ACDF showed significant clinical improvement (JOA, VAS, NDI) at 48 months.
• Mobi-C group maintained range of motion (ROM) and functional spinal unit (FSU) angle.
• ACDF group showed reduced ROM and higher rates of secondary surgery (4/56 patients).

Conclusions:

• Both Mobi-C TDR and ACDF are reliable for cervical spine treatment.
• Mobi-C demonstrated superior maintenance of cervical spine ROM and FSU angle.
• Mobi-C may reduce the risk of secondary surgery compared to ACDF.