Related Experiment Video
Updated: Apr 24, 2026
Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
Published on: October 3, 2018
Clinicopathological and molecular features of myeloid sarcoma as initial presentation of therapy-related myeloid
Deniz Peker1, Vishwas Parekh, Ravikumar Paluri
1Department of Pathology, University of Alabama, 1802 6th Ave South, NP 3552, Birmingham, AL, 35233-7331, USA, dpeker@uab.edu.
Abstract:
Therapy-related myeloid neoplasms (t-MN) have a common origin in prior cytotoxic therapy and/or radiation. These neoplasms include therapy-related acute myeloid leukemia, myelodysplastic syndrome (t-MDS), and myelodysplastic/myeloproliferative neoplasms (t-MDS/MPN). Myeloid sarcoma (MS), on the other hand, is a rare disease manifesting as an extramedullary collection of immature cells of myeloid lineage. Rarer still is therapy-related MS (t-MS), which has not been adequately studied due to its rarity and its lack of recognition as a unique entity among other t-MN. Here, we report what is to our knowledge the first case series of t-MS, with the aim of investigating and establishing salient clinicopathological and molecular features of this entity.
