Genetic variations associated with recurrent venous thrombosis

Astrid van Hylckama Vlieg1, Linda E Flinterman2, Lance A Bare2

  • 1From the Department of Clinical Epidemiology (A.v.H.V., L.E.F., S.C.C., F.R.R.), Department of Thrombosis and Haemostasis (P.H.R., F.R.R.), and Einthoven Laboratory for Experimental Vascular Medicine (A.v.H.V., S.C.C., P.H.R., F.R.R.), Leiden University Medical Center, Leiden, the Netherlands; and Celera, Alameda, CA (L.A.B., A.R.A., C.H.T., J.J.D.). a.van_hylckama_vlieg@lumc.nl.

Summary

Multiple genetic markers (SNPs) can predict recurrent venous thrombosis. A genetic risk score combining 31 or 5 SNPs improves prediction accuracy, especially with clinical factors.

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