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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Renewal of Skin Epidermal Stem Cells01:12

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Acne Infection01:27

Acne Infection

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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Tissue Renewal without Stem Cells01:23

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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Related Experiment Video

Updated: Apr 24, 2026

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
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Skin resurfacing procedures: new and emerging options.

Mathew M Loesch1, Ally-Khan Somani1, Melanie M Kingsley1

  • 1Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, USA.

Clinical, Cosmetic and Investigational Dermatology
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Advancements in skin resurfacing offer faster healing and fewer side effects for patients. New technologies enable treatment for more skin types and conditions, improving outcomes.

Keywords:
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Area of Science:

  • Dermatology
  • Cosmetic Surgery
  • Medical Aesthetics

Background:

  • Increasing patient demand for skin rejuvenation procedures.
  • Need for treatments with reduced downtime and side effects.
  • Evolution of skin resurfacing technologies.

Purpose of the Study:

  • To review current and emerging skin resurfacing therapies.
  • To highlight technological advancements in the field.
  • To discuss the expanded capabilities of new treatments.

Main Methods:

  • Literature review of recent advancements in skin resurfacing.
  • Analysis of emerging technologies and procedural developments.
  • Discussion of clinical integration and patient outcomes.

Main Results:

  • Significant progress in minimizing patient downtime and side effects.
  • Development of technologies suitable for a wider range of skin types.
  • Improved treatment outcomes for various skin pathologies.

Conclusions:

  • Emerging skin resurfacing therapies offer enhanced patient benefits.
  • Technological innovations are expanding treatment possibilities.
  • The field is rapidly evolving with new treatments becoming available.