Related Experiment Video
Updated: Apr 24, 2026
Establishment and Characterization of UTI and CAUTI in a Mouse Model
Published on: June 23, 2015
Clinical options for the treatment of urinary tract infections in children
Shammi Ramlakhan1, Virendra Singh2, Joanne Stone3
1Emergency Department, Sheffield Children's Hospital, Sheffield, UK.
Insights
Urinary Tract Infections (UTI) are common in children. Understanding antibiotic resistance is crucial for effective treatment and preventing complications.
Area of Science:
- Pediatric infectious diseases
- Microbiology
- Pharmacology
Background:
- Urinary Tract Infections (UTI) are a frequent cause of febrile illness in children, affecting 7% of girls and 2% of boys by age six.
- Conflicting views exist regarding long-term sequelae and the role of prophylaxis in childhood UTIs.
- Universal treatment goals include symptom relief, preventing systemic infection, and avoiding short and long-term complications.
Purpose of the Study:
- To highlight the importance of rationalizing antibiotic prescription patterns for childhood UTIs.
- To emphasize the need to consider historical and emerging antibiotic resistance patterns.
- To advocate for the re-examination of empirical antibiotic choices based on local sensitivities.
Main Methods:
- Review of historical and emerging antibiotic resistance patterns in childhood UTIs.
- Analysis of current prescription patterns and their impact on therapeutic effectiveness.
- Examination of evidence regarding optimal antibiotic duration and choice.
Main Results:
- Evidence indicates significant historical and emerging antibiotic resistance in UTIs.
- Rationalizing prescription patterns based on known sensitivities is essential.
- Re-evaluation of empirical antibiotic choices is necessary.
Conclusions:
- Local formularies must incorporate geographical resistance patterns for effective UTI management.
- Antibiotic selection and duration should be guided by best evidence to maximize efficacy.
- Minimizing the development of resistant strains is a critical objective in treating childhood UTIs.
Abstract:
Urinary Tract Infections (UTI) are a common cause of childhood febrile illness with 7% of girls and 2% of boys having a symptomatic culture positive UTI by the age of six years. Although there are conflicting views on the long term sequelae of UTI, as well as the place of prophylaxis, the universal aims of treatment of childhood UTI remain those of symptom alleviation, prevention of systemic infection and short and longer term complications. There is good evidence of historical and emerging resistance patterns, therefore rationalisation of prescription patterns by knowledge of sensitivities coupled with re-examination of empirical antibiotic choices is clearly important. Local formularies should reflect geographical resistance patterns along with best evidence on the duration and choice of antibiotic in order to maximize therapeutic effect, while minimizing the development of resistant strains.
More Related Videos
07:34Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis
Published on: April 16, 2019
10:23Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice
Published on: December 1, 2017
Related Concept Videos
01:30Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
01:17Urinary Tract Infection IV: Nursing Management
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
01:26Urinary Tract Infection I: Introduction
01:30Urinary Tract Calculi III: Medical Management
01:26Urine Studies II: Urine Culture and Sensitivity Test