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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
Malignant priapism secondary to isolated penile metastasis from a renal pelvic carcinoma
Sulai Liu1, Fuhua Zeng2, Lin Qi3
1Department of Urology, Xiangya Hospital, The Central South University, Changsha China; ; Department of Urology, The Affiliated Tumor Hospital of Xiangya Medical School, The Central South University, Changsha, China;
Abstract:
We report a case of isolated penile metastasis from renal pelvic carcinoma in a 69-year-old man with malignant priapism. The patient had radical resection of the renal pelvic carcinoma 2 months earlier with urothelial carcinoma (UC) and sarcomatoid differentiation histology. Physical examination showed no visible skin lesions, but a palpable hard nodule was present over the penile shaft. The imaging studies did not reveal other metastases. Cavernous-Glans shunt and nodule resection were performed, and histological examination showed metastasis UC with sarcomatoid differentiation. To our knowledge, we describe the first case of malignant priapism due to isolated penile metastasis of renal pelvic carcinoma.
Insights
This study details a rare case of malignant priapism caused by isolated penile metastasis from renal pelvic carcinoma. This finding highlights an unusual presentation of advanced urothelial carcinoma with sarcomatoid differentiation.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Renal pelvic carcinoma can metastasize to various sites.
- Malignant priapism is a rare condition often associated with hematologic malignancies.
- Penile metastasis from genitourinary cancers is uncommon.
Purpose of the Study:
- To report the first known case of malignant priapism secondary to isolated penile metastasis from renal pelvic carcinoma.
- To describe the clinical presentation, diagnostic findings, and histological characteristics of this rare event.
Main Methods:
- A 69-year-old male patient with a history of renal pelvic carcinoma underwent evaluation for priapism.
- Physical examination, imaging studies, and surgical intervention (cavernous-glans shunt and nodule resection) were performed.
- Histopathological examination of the resected penile nodule was conducted.
Main Results:
- The patient presented with priapism and a palpable penile nodule.
- Imaging revealed no other metastatic sites.
- Histology confirmed metastatic urothelial carcinoma with sarcomatoid differentiation in the penile nodule.
Conclusions:
- Isolated penile metastasis from renal pelvic carcinoma can present as malignant priapism.
- This case represents a unique and previously undescribed manifestation of advanced urothelial carcinoma.
- Early recognition and appropriate management are crucial for such rare oncological emergencies.
