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Fusarium napiforme systemic infection: case report with molecular characterization and antifungal susceptibility

Marcela de Souza1, Tetsuhiro Matsuzawa2, Luzia Lyra3

  • 1Department of Internal Medicine, School of Medicine, University of Campinas, Campinas, São Paulo Brazil ; LIM 46 - Laboratory of Parasitology - HC/FMUSP, Kragujevac, São Paulo Brazil.

Springerplus
|September 12, 2014
PubMed
Abstract

Insights

Disseminated fusariosis caused by Fusarium napiforme is rare, particularly in immunocompromised patients. This case highlights the need for rapid diagnostics and effective antifungal treatments for invasive Fusarium infections.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Clinical Case Study

Background:

  • Fusarium species are increasingly recognized as significant pathogens in humans, especially immunocompromised individuals.
  • Invasive, life-threatening infections caused by Fusarium spp. pose a considerable risk.
  • Commonly implicated species include Fusarium solani, Fusarium oxysporum, and Fusarium verticillioides.

Purpose of the Study:

  • To report the second documented case of disseminated fusariosis caused by Fusarium napiforme.
  • To detail the clinical presentation and diagnostic findings in a patient with multiple myeloma undergoing chemotherapy.
  • To evaluate the antifungal susceptibility profile of the isolated Fusarium napiforme.

Main Methods:

  • Morphological identification (macroscopic and microscopic) of Fusarium napiforme.
  • Molecular methods, including sequencing, for definitive species identification.
  • Antifungal susceptibility testing against seven antifungal drugs.

Main Results:

  • The patient, a 60-year-old woman with multiple myeloma, developed disseminated fusariosis after chemotherapy.
  • Fusarium napiforme was identified using both traditional and molecular techniques.
  • Azoles demonstrated the highest in vitro activity against the F. napiforme isolates.

Conclusions:

  • Fusarium species are clinically relevant fungal pathogens.
  • The observed low susceptibility to certain antifungal drugs underscores the need for improved diagnostic methods.
  • Faster and more accurate diagnostics are crucial for timely and effective treatment of invasive fusariosis.
Keywords:
FusariosisImmunocompromised hostOpportunistic Infections

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