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Updated: Apr 24, 2026
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Prognostic factors in pediatric differentiated thyroid cancer patients with pulmonary metastases
Insights
In pediatric differentiated thyroid cancer (DTC) with lung metastases, older age, large nodules, and less extensive surgery predict poorer remission. Understanding these factors aids in managing pediatric DTC outcomes.
Area of Science:
- Pediatric Oncology
- Endocrinology
- Cancer Research
Background:
- Pediatric differentiated thyroid cancer (DTC) with pulmonary metastases presents unique challenges in predicting remission.
- Limited data exists on prognostic factors specifically for this demographic with lung involvement.
Purpose of the Study:
- To identify prognostic factors associated with remission in pediatric DTC patients with initial pulmonary metastases.
- To elucidate the disease course and predictive markers for treatment response in this patient group.
Main Methods:
- Retrospective analysis of 53 pediatric DTC patients (age ≤21 years) with pulmonary metastases at diagnosis.
- Comparison of demographic and disease characteristics between patients who achieved remission and those who did not.
Main Results:
- Remission was achieved in 38 patients, while 14 had persistent disease, and one died.
- Factors associated with reduced remission odds included age >15 years, macronodular pulmonary metastases, and subtotal thyroidectomy.
Conclusions:
- Age, metastatic burden (macronodular), and surgical extent are significant prognostic factors for remission in pediatric DTC with pulmonary metastases.
- This study provides crucial insights into the disease course and identifies key predictors for managing pediatric DTC patients with lung metastases.
Aim:
This study was aimed at identifying the prognostic factors predicting remission in pediatric differentiated thyroid cancer (DTC) patients presenting with pulmonary metastases. Little is known about the prognostic factors in reference to pediatric DTC patients presenting with pulmonary metastases.
Methods:
Fifty-three DTC patients aged ≤21 years were diagnosed with pulmonary metastases at initial presentation. The demographic and disease characteristics were compared between the patients who achieved remission and those who did not.
Results:
During the median follow-up of 72 months, 38 patients became disease free, 14 patients had biochemically and/or structurally persistent disease, and one patient died due to disease progression. Patient age >15 years, presence of macronodular pulmonary metastases, and surgical methods lesser than total/near-total thyroidectomy were identified as factors associated with reduced odds of remission.
Conclusion:
This study describes the disease course and depicts the disease related prognostic factors in pediatric DTC patients with pulmonary metastases.
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