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Accuracy of a probabilistic record-linkage methodology used to track blood donors in the Mortality Information System
Ligia Capuani1, Ana Luiza Bierrenbach2, Fatima Abreu1
1Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brasil.
Insights
Probabilistic record linkage accurately tracks blood donors from the Fundação Pró-Sangue (FPS) to the Mortality Information System (SIM). This method enables future studies on blood donor causes of death.
Area of Science:
- Biomedical Informatics
- Public Health
- Epidemiology
Background:
- Screening test results for various diseases are available for blood donors.
- Tracking blood donors is crucial for understanding mortality patterns.
- Existing systems lack comprehensive donor mortality data.
Purpose of the Study:
- To evaluate the accuracy of a probabilistic record linkage (PRL) process.
- To link blood donors from Fundação Pró-Sangue (FPS) to the Mortality Information System (SIM).
- To facilitate future studies on blood donor causes of death.
Main Methods:
- Utilized databases from SIM and FPS, including living and deceased individuals.
- Implemented a PRL process with three blocking steps.
- Compared variables: Name, Mother's Name, and Date of Birth to establish a cut-off score.
Main Results:
- A cut-off score of 7.06 yielded high accuracy.
- Sensitivity reached 94.4% (95%CI: 90.0-97.0).
- Specificity was 100% (95%CI: 98.0-100.0).
Conclusions:
- The described PRL method is accurate for tracking blood donors.
- This linkage enables vital research into blood donor mortality.
- The methodology supports epidemiological studies using linked health data.
Abstract:
The probabilistic record linkage (PRL) is based on a likelihood score that measures the degree of similarity of several matching variables. Screening test results for different diseases are available for the blood donor population. In this paper, we describe the accuracy of a PRL process used to track blood donors from the Fundação Pró-Sangue (FPS) in the Mortality Information System (SIM), in order that future studies might determine the blood donor's cause of death. The databases used for linkage were SIM and the database made up of individuals that were living (200 blood donors in 2007) and dead (196 from the Hospital das Clinicas de São Paulo that died in 2001-2005). The method consists of cleaning and linking the databases using three blocking steps comparing the variables "Name/Mother's Name/ Date of Birth" to determine a cut-off score. For a cut-off score of 7.06, the sensitivity and specificity of the method is 94.4% (95%CI: 90.0-97.0) and 100% (95%CI: 98.0-100.0), respectively. This method can be used in studies that aim to track blood donors from the FPS database in SIM.
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