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Brain iron in progressive supranuclear palsy: clinical, magnetic resonance imaging, and neuropathological findings
C E Coffey1, S Alston, E R Heinz
1Department of Medicine (Neurology), Duke University Medical Center, Durham, NC 27710.
The Journal of Neuropsychiatry and Clinical Neurosciences
|January 1, 1989
Abstract:
A patient with progressive supranuclear palsy demonstrated a region-specific decrease in T2 signal during high-field-strength brain magnetic resonance imaging. At autopsy the T2-signal hypointensity was found to correspond topographically to increased deposition of ferric iron. The potential clinical, radiologic, and pathophysiologic implications of these findings are discussed.