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Updated: Apr 24, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Rare association between penile squamous cell carcinoma and parathyroid related peptide (PTH-rP) secretion
Rogelio Trejo-Rosales1, Maria J Nevarez-Barragan2, Mercedes G Rosas-Jurado2
1Division of Medicine, Instituto Nacional de Ciencias Medicas y Nutricion ?Salvador Zubiran?, Mexico City, Mexico.
Abstract:
We report on a rare case of an adult with severe hypercalcemia secondary to the ectopic secretion of parathyroid-related peptide (PTH-rP) from a penile squamous cell cancer (PC). A patient of 47 years old was admitted with warty lesions and areas of ulceration covered by purulent material in a large area of the groin, scrotum and penis. Laboratory tests revealed severe hypercalcemia and elevation of PTH-rP; the biopsy reported PC. Hypercalcemia was successfully treated with zoledronic acid, however, the tumor displayed aggressive behavior, which resulted in a poor prognosis for the patient.
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