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Related Experiment Video

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Pediatric brain tumor cell lines.

Jingying Xu1, Ashley Margol, Shahab Asgharzadeh

  • 1Division of Hematology, Oncology and Blood & Marrow Transplantation, Department of Pediatrics, Children's Hospital Los Angeles and the Keck School of Medicine, University of Southern California, Los Angeles, California, 90027.

Journal of Cellular Biochemistry
|September 12, 2014
PubMed
Summary

Pediatric brain tumors are the most common childhood cancer. This resource lists and describes ~60 pediatric brain tumor cell lines to aid researchers in selecting appropriate models for cancer research and therapy development.

Keywords:
ATRTEPENDYMOMAGLIOMAMEDULLOBLASTOMAPEDIATRIC BRAIN TUMOR CELL LINES

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Area of Science:

  • Oncology
  • Pediatric Medicine
  • Cancer Biology

Background:

  • Pediatric brain tumors are the most common solid tumors in children and a leading cause of cancer-related death.
  • Brain tumor cell lines are essential for understanding tumor biology and for preclinical therapeutic screening.
  • Selecting appropriate cell lines is crucial, as experimental outcomes can vary based on tumor-specific properties.

Purpose of the Study:

  • To compile a comprehensive list of currently available pediatric brain tumor cell lines.
  • To summarize key features of these cell lines for researchers.
  • To provide a valuable resource for scientists in the field of pediatric neuro-oncology.

Main Methods:

  • Literature review to identify published pediatric brain tumor cell lines.
  • Data extraction on central features of each cell line.
  • Compilation and summarization of gathered information.

Main Results:

  • Identification of approximately 60 distinct pediatric brain tumor cell lines reported in the literature.
  • Summary of key characteristics for each cell line, facilitating informed selection.
  • Highlighting the underutilization of the full spectrum of available cell lines in published research.

Conclusions:

  • A comprehensive catalog of ~60 pediatric brain tumor cell lines is presented.
  • This resource aims to improve the selection and utilization of cell lines in pediatric brain tumor research.
  • Enhanced use of diverse cell lines can lead to more robust and applicable findings in cancer therapy development.