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Related Concept Videos

Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

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Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
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Asthma I: Introduction01:28

Asthma I: Introduction

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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

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Severe asthma in children.

Theresa W Guilbert1, Leonard B Bacharier2, Anne M Fitzpatrick3

  • 1Division of Pulmonology Medicine, Department of Pediatrics, Cincinnati Children's Hospital, Cincinnati, Ohio.

The Journal of Allergy and Clinical Immunology. in Practice
|September 13, 2014
PubMed
Summary
This summary is machine-generated.

Severe asthma in children involves persistent symptoms despite high-dose treatments. Identifying and addressing factors like incorrect diagnosis or environmental influences is key to improving management for difficult-to-treat or therapy-resistant asthma.

Keywords:
Childhood difficult-to-treat asthmaChildhood severe asthmaChildhood severe asthma treatmentReviewSevere asthma phenotypes

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Area of Science:

  • Pediatric Pulmonology
  • Allergy and Immunology
  • Clinical Therapeutics

Background:

  • Severe asthma in children presents persistent symptoms, often unresponsive to standard high-dose inhaled or oral corticosteroids.
  • Children with severe asthma are categorized into difficult-to-treat or severe therapy-resistant groups.
  • Current treatment guidelines for severe childhood asthma largely rely on extrapolated adult data.

Purpose of the Study:

  • To highlight the heterogeneity of severe asthma in children, including distinct clinical and inflammatory phenotypes.
  • To emphasize the importance of accurate diagnosis and management of contributing factors for difficult-to-treat asthma.
  • To advocate for phenotype-targeted therapeutic strategies to improve treatment outcomes.

Main Methods:

  • Review of current understanding and classification of severe asthma in pediatric populations.
  • Analysis of diagnostic challenges and adherence issues contributing to difficult-to-treat asthma.
  • Examination of current guideline-based pharmacotherapy and its limitations.

Main Results:

  • Severe asthma is heterogeneous, with identifiable phenotypes in children.
  • Difficult-to-treat asthma stems from misdiagnosis, comorbidities, or psychosocial/environmental factors.
  • Therapy-resistant asthma is defined by poor control despite addressing these factors.

Conclusions:

  • Accurate diagnosis and management of contributing factors are crucial for controlling difficult childhood asthma.
  • Phenotypic characterization is essential for tailoring effective therapeutic interventions.
  • Future improvements in severe pediatric asthma treatment depend on personalized, phenotype-based approaches.