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Updated: Apr 24, 2026

Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone
Published on: April 8, 2015
Understanding, treating and avoiding hematological disease: better medicine through mathematics?
David C Dale1, Michael C Mackey
1Department of Medicine, University of Washington, Seattle, WA, 98195, USA, dcdale@u.washington.edu.
Abstract:
This paper traces the experimental, clinical and mathematical modeling efforts to understand a periodic hematological disease-cyclical neutropenia. It is primarily a highly personal account by two scientists from quite different backgrounds of their interactions over almost 40 years and their attempts to understand this intriguing disease. It's also a story of their efforts to offer effective treatments for the patients who suffer from cyclic neutropenia and other conditions causing neutropenia and infections.
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