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Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction
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Increased secretion of atrial natriuretic polypeptide from the left ventricle in patients with dilated cardiomyopathy

H Yasue1, K Obata, K Okumura

  • 1Division of Cardiology, Kumamoto University Medical School, Japan.

The Journal of Clinical Investigation
|January 1, 1989
PubMed

Insights

Patients with dilated cardiomyopathy (DCM) show increased release of atrial natriuretic polypeptide (ANP) from the left ventricle. This study measured ANP levels in DCM patients and controls, revealing significant cardiac ANP secretion in DCM.

Area of Science:

  • Cardiology
  • Endocrinology
  • Physiology

Background:

  • Dilated cardiomyopathy (DCM) is a significant cause of heart failure.
  • Atrial natriuretic polypeptide (ANP) plays a crucial role in cardiovascular homeostasis.
  • Understanding the source of ANP release in DCM is vital for therapeutic strategies.

Purpose of the Study:

  • To investigate whether the left ventricle releases atrial natriuretic polypeptide (ANP) in patients with dilated cardiomyopathy (DCM).
  • To quantify and compare ANP levels in different cardiac vessels between DCM patients and healthy controls.

Main Methods:

  • Plasma ANP levels were measured in the aortic root (Ao), anterior interventricular vein (AIV), great cardiac vein (GCV), and coronary sinus (CS).
  • Measurements were taken from 11 patients with DCM and 18 control subjects.
  • Statistical analysis compared ANP levels and differences between sampling sites in both groups.

Main Results:

  • Patients with DCM exhibited significantly higher ANP levels in the AIV and CS compared to the Ao.
  • A significant 'step-up' in plasma ANP levels was observed between the Ao and AIV in DCM patients (P < 0.001).
  • The difference in ANP levels between Ao and CS was also significantly greater in DCM patients (P < 0.001).

Conclusions:

  • Atrial natriuretic polypeptide (ANP) is released in increased amounts from the left ventricle in patients with dilated cardiomyopathy (DCM).
  • The heart as a whole demonstrates elevated ANP secretion in DCM.
  • These findings highlight the left ventricle as a significant source of ANP in DCM.

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