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Related Concept Videos

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Related Experiment Video

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Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing
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Sensory innervation around immediately vs. delayed loaded implants: a pilot study.

Yan Huang1, Jeroen van Dessel2, Wendy Martens3

  • 11] Department of Imaging & Pathology, Faculty of Medicine, University of Leuven and Oral & Maxillo-facial Surgery, University Hospitals Leuven, Leuven, Belgium [2] State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

International Journal of Oral Science
|September 13, 2014
PubMed
Summary
This summary is machine-generated.

Immediate implant placement and immediate loading (IIP+IL) promotes superior peri-implant re-innervation compared to other protocols. This study provides histomorphometric evidence for enhanced nerve fiber density and altered fiber characteristics in the IIP+IL group.

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Area of Science:

  • Oral surgery and implantology
  • Neuroscience
  • Histology

Background:

  • Osseoperception, the ability to sense bone, is supported by growing neurophysiological and psychophysical evidence.
  • However, histomorphometric data on the neural mechanisms of functional compensation after immediate and delayed implant loading remains limited.

Purpose of the Study:

  • To investigate the histomorphometric evidence of neural mechanisms in functional compensation following immediate implant placement and immediate loading (IIP+IL) versus delayed protocols.
  • To compare peri-implant innervation across different loading conditions.

Main Methods:

  • A randomized split-mouth study in six mongrel dogs over 16 weeks.
  • Four treatment protocols were applied: IIP+IL, delayed implant placement and delayed loading (DIP+DL), delayed implant placement and immediate loading (DIP+IL), and a control group.
  • Histomorphometry, immunocytochemistry, and transmission electron microscopy were used to analyze peri-implant bone and soft tissues.

Main Results:

  • Myelinated nerve fibers were found in peri-implant crestal gingival, apical regions, woven bone, and osteons.
  • The IIP+IL group showed significantly higher innervation density and smaller nerve fiber and axon diameters in the middle peri-implant region compared to the control.
  • In the apical region, IIP+IL demonstrated higher nerve density, greater fiber and axon diameters, and a lower g-ratio compared to DIP+IL.

Conclusions:

  • The IIP+IL protocol appears to be superior for optimizing peri-implant re-innervation.
  • Further functional assessments are necessary to fully understand the implications of these findings.