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The effect of chemonucleolysis on serum keratan sulfate levels in humans
J A Block1, T J Schnitzer, G B Andersson
1Department of Internal Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612-3864.
Arthritis and Rheumatism
|January 1, 1989
Abstract:
Sensitive measurements of serum keratan sulfate (KS), a glycosaminoglycan found in large quantities in the proteoglycans of human cartilage, can be obtained using an enzyme-linked immunosorbent-inhibition assay. Patients who are undergoing chemonucleolysis (CN) provide a clinical opportunity to monitor the large-scale proteolytic degradation of cartilage. By measuring serum KS levels both pre- and post-CN, we have demonstrated that serum KS levels rise predictably after CN, in a manner that reflects major catabolic events of cartilage.