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Microfluidics in Assessing Platelet Function
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Decreased mean platelet volume in panic disorder
Işıl Göğçegöz Gül1, Gül Eryılmaz1, Eylem Ozten1
1Neuropsychiatry Health, Practice, and Research Center, Uskudar University, Istanbul, Turkey.
Neuropsychiatric Disease and Treatment
|September 13, 2014
Summary
Mean platelet volume (MPV) was significantly lower in individuals with panic disorder (PD) compared to healthy controls. This finding suggests platelet activity may reflect central nervous system changes in PD.
Area of Science:
- Neuroscience
- Psychiatry
- Hematology
Background:
- Platelet activation is linked to psychological stress and brain changes.
- Platelet 5-hydroxytryptamine (5-HT) and mean platelet volume (MPV) are studied in psychiatry.
- MPV indicates platelet function and may serve as a biomarker.
Purpose of the Study:
- To investigate potential differences in MPV among individuals diagnosed with panic disorder (PD).
- To explore the relationship between PD and platelet characteristics.
Main Methods:
- Included 37 drug-free adults (18-65 years) with PD and 45 healthy controls.
- Diagnoses were based on DSM-IV criteria.
- Measured and recorded platelet count and MPV for all participants.
Main Results:
- No significant differences in gender ratio, age, or BMI between PD and control groups.
- MPV was significantly lower in the PD group (8.8±0.9 fL) versus the control group (9.2±0.8 fL; P=0.02).
- All MPV values fell within the normal range (6.9-10.8 fL).
Conclusions:
- Lower MPV in PD patients suggests altered platelet activity mirroring central nervous system abnormalities, possibly related to 5-HT1A receptor function.
- Platelet activity measurements could be valuable tools in neuropsychiatric and psychopharmacological research.
- This research aids in understanding mental diseases and medication effects on the central nervous system.
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