Related Experiment Video
Updated: Apr 24, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Antibiotic prescription and cost patterns in a general intensive care unit
Norberto Krivoy1, Wissam Abed El-Ahal2, Yaron Bar-Lavie3
1Division of Medicine, Clinical Pharmacology Unit. Rambam Medical Center and B. Rappaport Faculty of Medicine, Technion-Israel Institute of Technology. Haifa ( Israel ).
Unlabelled:
Antibiotic prescription habits, cost pattern, and the prospective intervention in an Intensive Care Unit were analyzed.
Methods:
Data on antibiotic utilization and costs were collected prospectively from individual electronic charts from August 2003 to January 2004, and retrospectively from August to December 2002.
Results:
A total of 180 and 107 patients were surveyed in 2002 and 2003. In 2002, Piperacillin-Tazobactam (13.8%) and Imipenem/Cilastin (11.2%) were the most prescribed medications; while, in 2003, Vancomycin (12.6%) and Imipenem/Cilastin (11.3%) were prescribed, respectively. Total defined daily dose (DDD) and Drug Utilization 90% (DU90%) index for 2002 and 2003 were 2031.15 and 2325.90 DDDs (p>0.1) and 1777.57 and 2079.61 DU90%, respectively (p>0.1). The Median Total Cost /100 admission days (CI 95%) were NIS13,310 (11,110;18,420) and NIS13,860 (6,710;18,020) (p=0.66), respectively.
Conclusions:
Interventional programs should focus on promoting infectious control with rational antibiotic prescription aimed at minimizing the future emergence of bacterial resistance and futile expenses.
More Related Videos
Related Concept Videos
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Acute Pyelonephritis II: Diagnostic Studies and Management
Dosage Interval and Administration Route: Determination Methods
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

