Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Episodic angioedema with eosinophilia.

C Wolf1, H Pehamberger, S Breyer

  • 1Department of Dermatology I, University of Vienna, Medical School, Austria.

Journal of the American Academy of Dermatology
|January 1, 1989
PubMed
Summary

This study details a rare case of angioedema with eosinophilia in a 40-year-old woman. Findings suggest it is a T-helper cell-mediated disease, offering new insights into its pathogenesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nuclear Astrophysics in the Storage Ring: Background Suppressed Simultaneous Measurement of (p,γ) and (p,n) Reactions.

Physical review letters·2025
Same author

Shedding Light on the Origin of ^{204}Pb, the Heaviest s-Process-Only Isotope in the Solar System.

Physical review letters·2024
Same author

[Neural networks in addiction].

Tijdschrift voor psychiatrie·2024
Same author

<math></math> Ge( <math></math> ) cross section below 70 keV measured at n_TOF CERN.

The European physical journal. A, Hadrons and nuclei·2022
Same author

Rapid organocatalytic chirality analysis of amines, amino acids, alcohols, amino alcohols and diols with achiral iso(thio)cyanate probes.

Chemical science·2021
Same author

Neutron Capture on the s-Process Branching Point ^{171}Tm via Time-of-Flight and Activation.

Physical review letters·2020

Area of Science:

  • Immunology
  • Dermatology
  • Pathology

Background:

  • Angioedema with eosinophilia is a rare condition presenting with recurrent swelling and elevated eosinophil counts.
  • Understanding the underlying mechanisms is crucial for effective diagnosis and treatment.

Observation:

  • A 40-year-old woman experienced monthly episodes of angioedema, pruritic skin lesions, and fever.
  • Acute episodes were marked by significant eosinophilia, fluid retention, and decreased urine output.
  • Extensive workup excluded parasitic, autoimmune, and neoplastic causes.

Findings:

  • Immunologic studies revealed elevated serum IgM and IgE levels and increased circulating activated T-helper cells.
  • Skin biopsy showed dermal infiltration of lymphocytes and eosinophils, with eosinophil granule major basic protein deposition.

Related Experiment Videos

  • Immunophenotyping confirmed a predominance of T-helper cells expressing HLA-DR in the dermal infiltrate.

    • Implications:

    • The findings suggest that angioedema with eosinophilia is a T-helper cell-mediated disease.
    • This highlights the role of specific immune pathways in the pathogenesis of this condition.
    • Further research into T-helper cell modulation may offer novel therapeutic strategies.