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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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Oral acyclovir induced acute renal failure.
Jian-Biao Meng1, Xia Zheng1, Gen Zhang1
1ICU, Tongde Hospital of Zhejiang Province, Hangzhou 310012, China (Meng JB, Zhang G); ICU, First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310006, China (Zheng X, Fang Q).
World Journal of Emergency Medicine
|September 13, 2014
Summary
Oral acyclovir can cause acute renal failure (ARF), presenting with diverse symptoms like abdominal pain and changes in urination. Prompt treatment, including stopping acyclovir, ensures full recovery of kidney function.
Area of Science:
- Nephrology
- Pharmacology
Background:
- Investigating acute renal failure (ARF) linked to oral acyclovir use.
- Examining the clinical presentation and outcomes of acyclovir-induced ARF.
Purpose of the Study:
- To characterize the clinical features of acute renal failure (ARF) resulting from oral acyclovir.
- To assess the prognosis and treatment effectiveness for acyclovir-induced ARF.
Main Methods:
- Case study of a 45-year-old male patient presenting with symptoms of ARF.
- Documented clinical signs including abdominal pain, oliguria, hematuria, proteinuria, and elevated creatinine.
- Reviewed patient history of oral acyclovir intake for facial neuritis.
Main Results:
- The patient exhibited symptoms consistent with acyclovir-induced ARF.
- Renal function normalized completely after acyclovir discontinuation and supportive care.
- Continuous renal replacement therapy was administered for 54 hours.
Conclusions:
- Acute renal failure caused by acyclovir can manifest with varied clinical signs.
- Early diagnosis and active management, including drug cessation, lead to a favorable prognosis in acyclovir-induced ARF.
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