Related Experiment Video
Updated: Apr 24, 2026
Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
Published on: July 3, 2018
Serum uric acid in patients with acute ST-elevation myocardial infarction
Li Chen1, Xian-Lun Li1, Wei Qiao1
1Department of Cardiology, China-Japan Friendship Hospital, Beijing 100029, China.
Insights
Serum uric acid levels in ST-elevation myocardial infarction (STEMI) patients correlate with triglyceride levels and cardiac dysfunction. Hyperuricemia is linked to increased in-hospital major adverse cardiovascular events (MACE) in STEMI patients.
Area of Science:
- Cardiology
- Biochemistry
- Clinical Medicine
Background:
- Limited research exists on serum uric acid levels in acute ST-elevation myocardial infarction (STEMI).
- Assessing the clinical significance of serum uric acid in STEMI patients is crucial.
Purpose of the Study:
- To evaluate the clinical value of serum uric acid levels in patients diagnosed with acute ST-elevation myocardial infarction (STEMI).
- To investigate the association between serum uric acid levels and cardiovascular risk factors, coronary artery disease severity, and clinical outcomes in STEMI patients.
Main Methods:
- A retrospective study of 502 consecutive STEMI patients from January 2005 to December 2010.
- Comparison of lipid profiles, echocardiographic data, and in-hospital major adverse cardiovascular events (MACE) between hyperuricemia and non-hyperuricemia groups.
- Analysis of the relationship between serum uric acid levels and coronary artery disease extent using statistical methods (Student's t test, Chi-square test, Pearson's correlation).
Main Results:
- Serum uric acid levels showed a positive correlation with serum triglyceride levels.
- Hyperlipidemia and higher triglyceride levels were more prevalent in patients with hyperuricemia.
- Hyperuricemia was associated with increased left ventricular end-diastolic diameter, higher rates of systolic and diastolic dysfunction, and a greater likelihood of in-hospital MACE.
- No significant association was found between serum uric acid levels and the number of diseased coronary vessels.
Conclusions:
- Serum uric acid levels correlate with triglyceride levels but not with coronary artery disease severity in STEMI patients.
- Hyperuricemia in STEMI patients is linked to impaired left ventricular function (systolic and diastolic) and an increased risk of in-hospital MACE.
- Serum uric acid may serve as a potential biomarker for adverse outcomes in STEMI.
Background:
Few studies investigated serum uric acid levels in patients with acute Stelevation myocardial infarction (STEMI). The study was to assess the clinical value of serum uric acid levels in patients with acute ST-elevation myocardial infarction (STEMI).
Methods:
Totally 502 consecutive patients with STEMI were retrospectively studied from January 2005 to December 2010. The level of serum lipid, echocardiographic data and in-hospital major adverse cardiovascular events (MACE) in patients with hyperuricemia (n=119) were compared with those in patients without hyperuricemia (n=383). The relationship between the level of serum uric acid and the degree of diseased coronary artery was analyzed. All data were analyzed with SPSS version 17.0 software for Student's t test, the Chi-square test and Pearson's correlation coefficient analysis.
Results:
Serum uric acid level was positively correlated with serum triglyceride level. Hyperlipidemia was more common in hyperuricemia patients than in non-hyperuricemia patients (43.7% vs. 33.7%, P=0.047), and serum triglyceride level was significantly higher in hyperuricemia patients (2.11±1.24 vs. 1.78±1.38, P=0.014). But no significant association was observed between serum uric acid level and one or more diseased vessels (P>0.05). Left ventricular end-diastolic diameter (LVEDd) was larger in hyperuricemia patients than in non-hyperuricemia patients (53.52±6.19 vs. 52.18±4.89, P=0.041). The higher rate of left systolic dysfunction and diastolic dysfunction was discovered in hyperuricemia patients (36.4% vs. 15.1%, P<0.001; 68.2% vs. 55.8%, P=0.023). Also, hyperuricemia patients were more likely to have in-hospital MACE (P<0.05).
Conclusions:
Serum uric acid level is positively correlated with serum triglyceride level, but not with the severity of coronary artery disease. Hyperuricemia patients with STEMI tend to have a higher rate of left systolic dysfunction and diastolic dysfunction and more likely to have more in hospital MACE.
More Related Videos
18:11A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
Published on: December 28, 2012
05:26Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
Published on: May 28, 2019
Related Concept Videos
01:30Acute Coronary Syndrome I: Introduction
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:14Myocarditis III: Medical Management
01:28Acute Coronary Syndrome IV: Interprofessional Care