Related Experiment Video
Updated: Apr 24, 2026
10:31
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
790
Histone lysine methylation in diabetic nephropathy
Guang-dong Sun1, Wen-peng Cui1, Qiao-yan Guo1
1Department of Nephrology, Second Hospital of Jilin University, Changchun 130041, China.
Journal of Diabetes Research
|September 13, 2014
Summary
Histone methylation influences diabetic nephropathy (DN) and metabolic memory in diabetes. Targeting these epigenetic changes offers potential new therapies for kidney disease.
Area of Science:
- Nephrology
- Endocrinology
- Epigenetics
Background:
- Diabetic nephropathy (DN) is a major complication of diabetes, leading to kidney failure.
- DN can progress even with good glucose control due to "metabolic memory."
- Mechanisms driving DN and metabolic memory are not fully understood.
Purpose of the Study:
- To review recent advances in histone methylation.
- To explore the role of histone methylation in DN pathogenesis and progression.
- To highlight therapeutic potential of targeting histone methylation.
Main Methods:
- Review of cell culture and animal studies.
- Analysis of epigenetic mechanisms, specifically histone methylation.
- Focus on histone methyltransferases and demethylases.
Main Results:
- Histone methylation patterns are crucial in regulating inflammatory and profibrotic genes in diabetic kidney cells.
- Histone methylation is dynamic and reversible.
- Epigenetic modifications like histone methylation are implicated in DN and metabolic memory.
Conclusions:
- Histone methylation plays a significant role in the development and progression of diabetic nephropathy.
- The reversible nature of histone methylation presents therapeutic opportunities for DN.
- Further research into histone methylation could lead to novel treatments for diabetic kidney disease.
More Related Videos
10:09Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
Published on: January 26, 2018
6.8K
08:12Global Level Quantification of Histone Post-Translational Modifications in a 3D Cell Culture Model of Hepatic Tissue
Published on: May 5, 2022
3.6K
Related Concept Videos
01:28Diabetic Nephropathy
24
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration...
24
02:32Histone Modification
14.4K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
14.4K
01:26Type II Diabetes I: Introduction
8
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
8
01:26Type I Diabetes II: Pathophysiology
42
Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular...
42
01:24Type II Diabetes II: Pathophysiology
8
PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
8
01:22Diabetic Ketoacidosis ll: Pathophysiology
7
Diabetic ketoacidosis (DKA) is a metabolic emergency characterized by hyperglycemia, ketonemia, and metabolic acidosis. It results from severe insulin deficiency and an excess of counterregulatory hormones, leading to uncontrolled lipolysis, ketogenesis, and widespread electrolyte and fluid disturbances.Pathophysiology The central event in DKA is a profound loss of insulin action. Without insulin, glucose uptake in insulin-dependent tissues is impaired, while hepatic glucose production...
7