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Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats
Published on: March 13, 2012
Analysis of short-term effects of World Trade Center dust on rat sciatic nerve
Mark Stecker1, Jacqueline Segelnick, Marc Wilkenfeld
1From the Department of Neurosciences (Dr Stecker) and Division of Occupational and Environmental Medicine (Dr Wilkenfeld), Winthrop University Hospital; and Queens College and Winthrop University Hospital (Ms Segelnick), Mineola, N.Y.
Objective:
The purpose of this study was to investigate the short-term effects of residual dust from the World Trade Center (WTC) on rat sciatic nerve.
Methods:
Nerve action potentials were recorded in nerves exposed to dust from the WTC as well as control nerves.
Results:
There was a reduction in the conduction velocity of nerves exposed to a high concentration of the dust from the WTC when compared with controls.
Conclusions:
Although there are statistically significant reductions in conduction velocity when exposed to the WTC dust in this pilot study, additional studies both clinical and basic will be needed to further understand the significance of these results.
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