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Thyroid antigen-mediated glomerulonephritis in Graves' disease
1Surugadai Nihon University Hospital, Department of Cardiology, Tokyo, Japan.
Clinical Nephrology
|January 1, 1989
Abstract:
We describe a patient with Graves' disease in whom marked proteinuria, microhematuria and hypoalbuminemia were associated. Renal biopsy demonstrated electrondense deposits in the capillary basement membrane, a finding consistent with immune complex glomerulonephritis. Indirect immunofluorescent examination with rabbit antihuman thyroglobulin indicated that these electron-dense deposits were thyroid antigen-mediated immune complexes.