Related Experiment Video
Updated: Apr 24, 2026

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
Published on: March 23, 2022
Blepharoptosis and HAART related mitochondrial myopathy
Kristin Ow Chapman1, Gary Lelli
1Weill Cornell Medical Center , New York , USA.
Purpose:
To report a case of blepharoptosis in a patient with human immunodeficiency virus (HIV) on highly active antiretroviral therapy (HAART) with biopsy confirmed mitochondrial deletions consistent with HAART related myopathy.
Methods:
A 51-year-old man with HIV demonstrated visually significant ptosis after being on HAART therapy for over 20 years.
Results:
Muscle tissue biopsy following blepharoplasty was analyzed and found to have significant mitochondrial deletions.
Conclusions:
This patient represents a case of isolated ptosis consistent with acquired myopathy secondary to mitochondrial dysfunction without systemic manifestations otherwise seen in inherited mitochondrial disorders.
More Related Videos
07:50A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
09:40Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
Published on: January 19, 2017
Related Concept Videos
Lysosomal Hydrolases
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Myasthenia Gravis: Overview and Treatment
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
Photoreceptors and Visual Pathways
Cross-bridge Cycle
ATP Synthase: Mechanism