Related Experiment Video

Updated: Apr 24, 2026

Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia
07:48

Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia

Published on: June 8, 2019

8.2K

Urgent endovascular revascularization in acute on chronic critical limb ischemia

Nicola Troisi1, Leonardo Ercolini, Emiliano Chisci

  • 1Unit of Vascular and Endovascular Surgery, Department of Surgery, San Giovanni di Dio Hospital, Florence, Italy - nicola.troisi@alice.it.

The Journal of Cardiovascular Surgery
|September 13, 2014
PubMed

Insights

Urgent endovascular treatment is effective for acute on chronic critical limb ischemia (CLI), improving lesion healing and limb salvage. However, patients with Rutherford class 6 CLI showed fewer benefits from this approach.

Area of Science:

  • Vascular Surgery
  • Interventional Cardiology
  • Endovascular Therapy

Background:

  • Acute on chronic critical limb ischemia (CLI) presents a significant clinical challenge.
  • Evaluating early and one-year outcomes of urgent endovascular treatment is crucial for managing CLI.

Purpose of the Study:

  • To assess the efficacy and safety of urgent endovascular treatment for acute on chronic CLI.
  • To determine the early and one-year outcomes, including lesion healing, pain relief, and limb salvage.

Main Methods:

  • A cohort of 104 patients with acute on chronic CLI (Rutherford class 4-6) were analyzed.
  • Urgent endovascular revascularization was the primary treatment strategy.
  • Patients with extensive disease (e.g., long occlusions, massive gangrene) were excluded.

Main Results:

  • Seventy-seven patients underwent urgent endovascular treatment, predominantly males with leg/foot lesions.
  • Successful lesion healing and pain relief were achieved in 59.7% of patients.
  • One-year outcomes included primary patency (63.6%), assisted patency (68.3%), secondary patency (69%), and limb salvage (84.1%).

Conclusions:

  • Urgent endovascular treatment is a safe and effective option for selected acute on chronic CLI patients.
  • The procedure demonstrates good outcomes in lesion healing, pain relief, and limb salvage.
  • Patients classified as Rutherford class 6 experienced less favorable results with this intervention.
Abstract

More Related Videos

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

14.4K
Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound13:48

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound

Published on: April 21, 2023

2.3K

Related Concept Videos

Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
2.2K
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
649
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
481
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
514
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
624