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Mild method for succinimide hydrolysis on ADCs: impact on ADC potency, stability, exposure, and efficacy

L Nathan Tumey1, Manoj Charati, Tao He

  • 1Worldwide Medicinal Chemistry, ‡Global Biological Technologies, §Pharmacokinetics, Metabolism, and Distribution, and ∥Oncology Research Unit, Pfizer Global R&D , Groton, Connecticut 06340, United States.

Bioconjugate Chemistry
|September 13, 2014
PubMed

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