Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Postulated genetic linkage between manic-depression and stuttering.

P Hays1, L L Field

  • 1Department of Psychiatry, University of Alberta, Edmonton, Canada.

Journal of Affective Disorders
|January 1, 1989
PubMed
Summary

Genetic links between stuttering and bipolar disorder were found in three families. Further analysis suggests these conditions may share genes on linked chromosomal locations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of the ROBO1 gene with reading disabilities in a family-based analysis.

Genes, brain, and behavior·2014
Same author

A family-based association analysis and meta-analysis of the reading disabilities candidate gene DYX1C1.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics·2013
Same author

Dense-map genome scan for dyslexia supports loci at 4q13, 16p12, 17q22; suggests novel locus at 7q36.

Genes, brain, and behavior·2012
Same author

Association of AXIN2 with non-syndromic oral clefts in multiple populations.

Journal of dental research·2012
Same author

Pitfalls in accident and emergency chest pain evaluation.

Journal of the Royal Society of Medicine·2010
Same author

Murine pancreatic beta TC3 cells show greater 2', 5'-oligoadenylate synthetase (2'5'AS) antiviral enzyme activity and apoptosis following IFN-alpha or poly(I:C) treatment than pancreatic alpha TC3 cells.

Experimental diabetes research·2009

Area of Science:

  • Genetics
  • Psychiatry
  • Speech-Language Pathology

Background:

  • Stuttering and bipolar disorder are complex conditions with significant heritability.
  • Previous research has not established a direct genetic link between these two disorders.

Purpose of the Study:

  • To investigate the potential genetic association between stuttering and bipolar disorder.
  • To explore the possibility of linked genetic loci for both conditions within families.

Main Methods:

  • Pedigree recording for three families exhibiting both stuttering and bipolar illness.
  • Statistical association analysis to determine the relationship between the conditions.
  • Linkage analysis to assess the co-occurrence of genes on specific chromosomal regions.

Related Experiment Videos

Main Results:

  • A significant association was demonstrated between stuttering and bipolar disorder in the studied families.
  • Linkage analysis provided evidence suggesting that the genes responsible for stuttering and bipolar disorder may be located at linked loci.

Conclusions:

  • The findings suggest a potential shared genetic basis for stuttering and bipolar disorder.
  • Further research is warranted to elucidate the specific genes and mechanisms involved in this association.