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Treatment of infections by cryptic Aspergillus species

Wagner L Nedel1, Alessandro C Pasqualotto

  • 1Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil.

Mycopathologia
|September 14, 2014
PubMed

Insights

Treatment for invasive aspergillosis from cryptic Aspergillus species is uncertain. Standard first-line therapy is recommended, adjusted based on in vitro susceptibility testing for these challenging fungal infections.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Invasive aspergillosis is a serious fungal infection, often caused by Aspergillus species.
  • Cryptic Aspergillus species present diagnostic and therapeutic challenges due to limited clinical data.
  • Optimal treatment strategies for infections caused by these species are not well-established.

Purpose of the Study:

  • To review the significance of cryptic Aspergillus species in clinical settings.
  • To outline current knowledge on the prevalence and detection of cryptic Aspergillus species.
  • To summarize the antifungal drug susceptibility patterns for cryptic Aspergillus species.

Main Methods:

  • Literature review of published clinical data and in vitro studies.
  • Analysis of prevalence, diagnostic methods, and antifungal responses.
  • Synthesis of information on cryptic Aspergillus species and invasive aspergillosis.

Main Results:

  • Limited clinical data exists for invasive aspergillosis caused by cryptic Aspergillus species.
  • Standard first-line antifungal therapy for invasive aspergillosis is suggested as an initial approach.
  • In vitro susceptibility testing is crucial for guiding therapy modifications.

Conclusions:

  • Cryptic Aspergillus species pose a significant challenge in diagnosing and treating invasive aspergillosis.
  • A pragmatic approach involving standard therapy and susceptibility-guided adjustments is recommended.
  • Further research is needed to establish definitive treatment guidelines for these infections.

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