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Therapeutic interventions for frail elderly patients: part II. Ongoing and unpublished randomized trials

Melissa Bendayan1, Lior Bibas2, Michael Levi2

  • 1Department of Physiology, McGill University, Montreal, Canada.

Progress in Cardiovascular Diseases
|September 14, 2014
PubMed

Insights

This study reviewed frailty intervention trials for older adults with cardiovascular disease. It found diverse interventions like exercise, nutrition, and pharmaceuticals are being investigated to improve health outcomes.

Area of Science:

  • Gerontology and Geriatric Medicine
  • Cardiovascular Disease Research
  • Clinical Trial Analysis

Background:

  • Frailty is a key predictor of adverse outcomes in elderly patients, especially those with cardiovascular disease.
  • Measuring frailty in clinical practice is gaining importance.
  • The number of clinical trials focused on frail older adults remains limited.

Purpose of the Study:

  • To systematically review frailty intervention trials initiated or completed but not yet published.
  • To analyze the types of interventions being studied in frail older adults.
  • To provide an overview of study designs, populations, interventions, and outcomes.

Main Methods:

  • Systematic search of the ClinicalTrials.gov registry.
  • Inclusion of actively initiated or completed but unpublished frailty intervention trials.
  • Categorization of interventions including exercise, nutrition, pharmaceuticals, and multi-dimensional programs.

Main Results:

  • Exercise training (2 trials), nutritional supplementation (3 trials), and home-based services (3 trials) were investigated.
  • Combined exercise and nutritional supplementation (5 trials) and pharmaceutical agents (5 trials) were also common interventions.
  • Multi-dimensional programs were studied in 2 trials.

Conclusions:

  • A range of interventions are being explored to address frailty in older adults.
  • Further research is needed to understand the efficacy of these interventions.
  • This review highlights ongoing efforts to develop and test frailty interventions.
Keywords:
FrailtyRandomized clinical trialsSarcopenia

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