Related Experiment Video
Updated: Apr 24, 2026
Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions
Published on: November 17, 2021
Pediatric cerebral ganglioneuroblastoma
Sean P Steenberge1, Richard A Prayson1
1Cleveland Clinic Lerner College of Medicine and Department of Pathology, L25 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Insights
A rare pediatric brain tumor, primary intracranial ganglioneuroblastoma, was diagnosed in a 4-year-old girl presenting with headaches and vision loss. Treatment involved surgery, chemotherapy, and radiotherapy.
Area of Science:
- Pediatric Oncology
- Neuro-oncology
- Pathology
Background:
- Primary intracranial ganglioneuromas are rare tumors in children.
- Ganglioneuromas originate from neural crest cells.
Observation:
- A 4-year-old girl presented with acute headaches and transient blindness.
- An intracranial mass was identified as the cause.
Findings:
- The mass was surgically removed and pathologically confirmed as a primary intracranial ganglioneuroblastoma.
- This represents a rare pediatric central nervous system malignancy.
Implications:
- This case highlights the importance of considering rare tumors in pediatric neuro-oncology.
- Multimodal treatment including surgery, chemotherapy, and radiotherapy may be effective.
- Further research into pediatric primary intracranial ganglioneuroblastoma is warranted.
Abstract:
We describe a 4-year-old girl with acute onset headaches and transient blindness who underwent surgical intervention, chemotherapy, and radiotherapy for an intracranial mass. This mass was pathologically confirmed as a primary intracranial ganglioneuroblastoma, a rare finding in the pediatric population. The literature on pediatric primary intracranial ganglioneuroblastoma is reviewed.
