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The p53 control of apoptosis and proliferation: lessons from Drosophila

Bertrand Mollereau1, Dali Ma

  • 1Laboratory of Molecular Biology of the Cell, UMR5239 CNRS/Ecole Normale Supérieure de Lyon, UMS 3444 Biosciences Lyon Gerland, University of Lyon, Lyon, France, bertrand.mollereau@ens-lyon.fr.

Apoptosis : an International Journal on Programmed Cell Death
|September 14, 2014
PubMed

Insights

The tumor suppressor p53 (also known as Dmp53 in Drosophila) has new roles beyond genome protection. It also promotes cell division, enhances cell fitness, and coordinates organismal growth under stress, impacting cancer development.

Area of Science:

  • Molecular Biology
  • Genetics
  • Developmental Biology

Background:

  • The tumor suppressor p53 is crucial for maintaining genome stability and preventing cancer.
  • p53 regulates cellular responses to DNA damage, oncogene activation, and stress to maintain homeostasis.
  • Recent research in Drosophila has revealed novel functions for Dmp53.

Purpose of the Study:

  • To review the newly discovered functions of Dmp53 in Drosophila.
  • To discuss the implications of these novel Dmp53 functions in carcinogenesis.

Main Methods:

  • This review synthesizes findings from recent studies on Dmp53 in Drosophila.
  • Comparative analysis of Dmp53 functions with its mammalian counterpart, p53.

Main Results:

  • Dmp53 promotes cell division during apoptosis-induced proliferation.
  • Dmp53 enhances the fitness and proliferation of 'winner' cells in cell competition.
  • Dmp53 coordinates organ and organismal growth under stress conditions.

Conclusions:

  • Dmp53 exhibits functions beyond canonical tumor suppression, including roles in proliferation and growth coordination.
  • These newly identified Dmp53 functions may be relevant to understanding and potentially targeting carcinogenesis.

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