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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Tract-specific white matter degeneration in aging: the Rotterdam Study

Marius de Groot1, M Arfan Ikram2, Saloua Akoudad2

  • 1Department of Radiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Medical informatics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|September 14, 2014
PubMed
Summary

Brain white matter microstructure changes with normal aging, potentially indicating neurodegeneration earlier than traditional markers. Cardiovascular risk factors like hypertension and diabetes worsen these age-related microstructural changes.

Keywords:
AgingAtrophyDTIMicrostructureTractographyWMLWhite matter

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