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Related Concept Videos

Regulation of Food Intake01:30

Regulation of Food Intake

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Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
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Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
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Hormonal Regulation01:40

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Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
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Antidepressant Drugs: MAOIs and Other Agents01:23

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Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
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Neural Regulation01:37

Neural Regulation

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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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Primary Motives: Hunger and Thirst01:25

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Hunger and thirst are fundamental physiological drives crucial for maintaining homeostasis and ensuring the survival of both humans and animals. These drives are regulated through complex interactions between the brain, hormones, and sensory receptors.
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Related Experiment Video

Updated: Apr 24, 2026

Control of Eating Behavior Using a Novel Feedback System
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Serotonin controlling feeding and satiety.

Jörg-Peter Voigt1, Heidrun Fink1

  • 1School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK.

Behavioural Brain Research
|September 15, 2014
PubMed
Summary

Serotonin (5-HT) plays a key role in controlling satiety, influencing appetite through various receptor subtypes like 5-HT1B, 5-HT2C, and 5-HT6. Research continues to explore these complex interactions for developing new anti-obesity drugs.

Keywords:
5-HTCholecystokininFeeding behaviourHypothalamusLeptinObesity

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Endocrinology

Background:

  • Serotonin (5-HT) has been recognized for its role in satiety control for decades.
  • Initial research was spurred by the appetite-suppressant effects of fenfluramine, linked to serotonin.
  • Understanding serotonin's role in satiety is crucial for metabolic research.

Purpose of the Study:

  • To identify specific serotonin (5-HT) receptor subtypes involved in satiety.
  • To investigate the brain regions mediating serotonergic control of appetite.
  • To elucidate the interaction between serotonin and peripheral satiety signals.

Main Methods:

  • Utilized various rodent models, including transgenic approaches, to study 5-HT receptor subtypes.
  • Developed and employed behavioral techniques to distinguish specific satiety effects from general pharmacological actions.
  • Investigated drug mechanisms, such as the 5-HT2C agonist lorcaserin, in appetite regulation.

Main Results:

  • Identified 5-HT1B, 5-HT2C, and 5-HT6 receptors as key mediators of serotonergic satiety.
  • Pinpointed hypothalamic (arcuate, paraventricular nuclei) and extrahypothalamic (parabrachial, solitary tract nuclei) sites involved in satiety control.
  • Demonstrated serotonin's interaction with orexigenic and anorectic peptides and peripheral signals like cholecystokinin and leptin.

Conclusions:

  • Serotonin (5-HT) significantly influences satiety through multiple receptor subtypes and brain regions.
  • Serotonin interacts with central appetite-regulating peptides and peripheral satiety cues.
  • Further research into these complex interactions holds promise for developing novel anti-obesity therapeutics.