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Bisphosphonates and extrarenal acid buffering capacity.

H Freudiger¹, J P Bonjour

¹Department of Pathophysiology, University of Berne, Switzerland.

Calcified Tissue International

|January 1, 1989

Summary

Bisphosphonates impact the body's acid-base balance by affecting bone mineral. Different bisphosphonates influence buffering capacity differently, particularly when kidney function is impaired.

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Area of Science:

Physiology
Pharmacology
Bone Metabolism

Background:

Bone mineral and intracellular compartments contribute to extrarenal acid buffering.
Bisphosphonates are drugs that affect bone formation and resorption.
The impact of bisphosphonates on acid-base balance via bone buffering is not fully understood.

Purpose of the Study:

To investigate how bisphosphonates, with differing effects on bone, influence extrarenal acid buffering capacity.
To determine if bisphosphonates interfere with the release of bone proton buffers.
To assess the role of bisphosphonates in acid-base homeostasis under varying physiological conditions.

Main Methods:

Rats were pretreated with 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) or dichloromethylene bisphosphonate (Cl2MBP), or saline control.
Acid-base variables were measured in intact and nephrectomized rats before and after acid loading (HCl infusion).
Effects were assessed after a 24-hour fasting period in nephrectomized animals.

Main Results:

Neither HEBP nor Cl2MBP affected acid-base variables in intact rats.
HEBP pretreatment increased blood HCO3- and PCO2 in nephrectomized rats before acid loading.
Bisphosphonate pretreatment led to a transiently greater decrement in blood HCO3- after HCl infusion.
Cl2MBP pretreatment in nephrectomized, fasted rats resulted in significantly lower blood HCO3- and pH.

Conclusions:

Bisphosphonates influence extrarenal buffering capacity based on their effects on bone mineral formation or dissolution.
These drugs may alter the release rate of bone proton buffers.
The acid-base balance is not disturbed in the presence of normal renal function.

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