Prophylactic peritoneal dialysis catheter does not decrease time to achieve a negative fluid balance after the

Lindsay M Ryerson1, Andrew S Mackie1, Joseph Atallah2

  • 1Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

Insights

Prophylactic peritoneal dialysis catheter (PDC) insertion did not improve fluid balance post-Norwood procedure in neonates with hypoplastic left heart syndrome. The intervention also showed no physiological benefits and was linked to increased adverse events.

Area of Science:

  • Pediatric Cardiac Surgery
  • Neonatal Intensive Care
  • Fluid Management

Background:

  • Postoperative fluid overload is a significant risk for neonates undergoing cardiopulmonary bypass and cardiac surgery.
  • Peritoneal dialysis catheter (PDC) and peritoneal dialysis are recognized for their efficacy in managing fluid balance postoperatively.
  • Hypoplastic left heart syndrome (HLHS) necessitates complex surgical interventions like the Norwood procedure, often leading to fluid management challenges.

Purpose of the Study:

  • To evaluate the efficacy of prophylactic PDC insertion during the Norwood procedure in neonates with HLHS.
  • To determine if prophylactic PDC insertion reduces the time to achieve a negative fluid balance post-surgery.
  • To assess the impact of prophylactic PDC on physiological variables and clinical outcomes.

Main Methods:

  • A single-center randomized controlled trial was conducted.
  • Neonates with HLHS were randomized to either prophylactic PDC insertion (with or without dialysis) or standard care (no PDC).
  • Outcomes measured included time to negative fluid balance, lactate levels, vasoactive-inotrope scores, time to sternal closure, extubation, and hospital length of stay.

Main Results:

  • The mean time to achieve a negative fluid balance was similar between the prophylactic PDC group (2.70 days) and the standard care group (2.67 days) (P=.93).
  • No significant differences were observed in physiological variables, time to sternal closure, extubation, or hospital length of stay between the groups.
  • Four patients (36%) in the prophylactic PDC group experienced serious adverse events, compared to none in the standard care group (P=.03).

Conclusions:

  • Prophylactic PDC insertion did not accelerate the achievement of negative fluid balance after the Norwood procedure in neonates with HLHS.
  • The intervention did not demonstrate benefits in postoperative physiological parameters or clinical outcomes.
  • Prophylactic PDC was associated with a higher incidence of serious adverse events, suggesting potential risks outweighing benefits.
Abstract

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