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White matter lesions in myotonic dystrophy type 1 co-locate with dilated perivascular spaces

Dimitri Renard1, Guillaume Taieb1

  • 1Department of Neurology, CHU Nîmes, Hôpital Caremeau, Place du Pr Debré, 30029 Nîmes Cedex 4, France.

Clinical Neurology and Neurosurgery
|September 15, 2014
PubMed
Abstract

Insights

The study suggests a link between white matter lesions (WML) and dilated Virchow-Robin spaces (DVRS) in myotonic dystrophy 1 (DM1). Some WML may be pathologically altered DVRS, offering new insights into DM1 brain changes.

Area of Science:

  • Neurology
  • Neuroimaging
  • Myotonic Dystrophy Research

Background:

  • White matter lesions (WML) and dilated Virchow-Robin spaces (DVRS) are common in myotonic dystrophy 1 (DM1).
  • The underlying pathophysiological mechanisms linking WML and DVRS in DM1 remain poorly understood.

Purpose of the Study:

  • To investigate the spatial relationship between WML and DVRS in DM1 patients.
  • To explore potential shared pathophysiological pathways.

Main Methods:

  • Brain MRI scans (1.5T or 3T) were analyzed in 6 DM1 patients.
  • The co-existence and spatial arrangement of WML and DVRS were examined.

Main Results:

  • A significant co-localization of WML with DVRS was observed in 86% of cases.
  • WML exhibited various shapes (droplet, ovoid, finger-like, linear, streak, dotted) often oriented along DVRS.
  • Some WML appeared indistinguishable from DVRS on T2-weighted imaging.

Conclusions:

  • The findings suggest a pathophysiological connection between WML and DVRS in DM1.
  • Pathologically modified DVRS may contribute to the formation of WML in DM1.
Keywords:
MRIMyotonic dystrophy type 1White matter lesions

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