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Markers of fibrosis, inflammation, and remodeling pathways in heart failure

Claudio Passino1, Andrea Barison2, Giuseppe Vergaro2

  • 1Division of Cardiology and Cardiovascular Medicine, Fondazione G. Monasterio CNR-Regione Toscana, Italy; Scuola Superiore Sant'Anna, Pisa, Italy.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|September 15, 2014
PubMed

Insights

Ventricular remodeling, a process involving heart muscle changes after infarction or heart failure, can be monitored using biomarkers. Detecting these markers may help guide treatment strategies for better patient outcomes.

Area of Science:

  • Cardiology
  • Biomarker Research
  • Pathophysiology

Background:

  • Ventricular remodeling is a progressive pathological process following myocardial infarction or in cardiomyopathy.
  • It involves changes in left ventricular (LV) volume, geometry, myocytes, non-myocyte cells, and extracellular matrix.

Purpose of the Study:

  • To explore the role of biomarkers in detecting ongoing ventricular remodeling.
  • To assess the potential clinical value of biomarkers in guiding therapeutic strategies for patients with myocardial infarction or heart failure.

Main Methods:

  • Review of mechanisms underlying ventricular remodeling, including inflammation, fibrosis, neuro-hormonal activation, and myocardial damage.
  • Identification and discussion of various biomarkers (cytokines, troponins, neurohormones, metalloproteinases, galectin-3, ST-2) used for detecting remodeling.

Main Results:

  • Biomarkers such as cytokines, troponins, and others can indicate an ongoing remodeling process.
  • The detection of these biomarkers may offer clinical value in managing patients post-myocardial infarction or with heart failure.

Conclusions:

  • Biomarkers show promise for detecting and potentially guiding treatment for ventricular remodeling.
  • Further research is needed to establish the clinical utility of newly proposed laboratory tests for these conditions.

Keywords:
FibrosisHeart failureRemodeling

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