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Alteration of HDL functionality and PON1 activities in acute coronary syndrome patients

Abdelghani Bounafaa1, Hicham Berrougui2, Souade Ikhlef3

  • 1Laboratory of Biochemistry & Neuroscience, Applied Biochemistry and Toxicology Team, Hassan I University, Faculty of Sciences and Technology, Settat, Morocco; Department of Biology, Polydisciplinary Faculty, Sultan Moulay Sliman University, Beni-Mellal, Morocco; Laboratory of Biochemistry, Pasteur Institute of Morocco, Casablanca, Morocco; Department of Medicine, Geriatrics Service, Faculty of Medicine and Biological Sciences, University of Sherbrooke, Sherbrooke, Quebec, Canada.

Clinical Biochemistry
|September 15, 2014
PubMed

Insights

High-density lipoprotein (HDL) functionality is impaired in acute coronary syndrome (ACS) patients, linked to oxidative stress and altered PON1 activities. These findings suggest potential therapeutic targets for cardiovascular disease prevention.

Area of Science:

  • Cardiovascular Science
  • Biochemistry
  • Genetics

Background:

  • High-density lipoprotein (HDL) plays a crucial role in preventing cardiovascular diseases.
  • Understanding HDL functionality in acute coronary syndrome (ACS) is vital for developing effective treatments.

Purpose of the Study:

  • To investigate HDL functionality in ACS patients.
  • To identify factors influencing HDL's anti-atherogenic properties in ACS.

Main Methods:

  • Compared HDL cholesterol efflux capacity between 205 ACS patients and 100 healthy controls.
  • Assessed oxidative stress markers (MDA, protein carbonyl, vitamin E) and PON1 Q192R polymorphism.
  • Measured PON1 paraoxonase and arylesterase activities in relation to HDL levels.

Main Results:

  • ACS patients exhibited reduced HDL cholesterol efflux capacity, particularly via the ABCA1 pathway.
  • Elevated oxidative stress markers (MDA, protein carbonyl) and reduced vitamin E levels were observed in ACS patients.
  • Lower paraoxonase, arylesterase, and HDL-corrected PON1 activities were found in ACS patients, with higher PON1 activities showing a protective effect.

Conclusions:

  • HDL functionality is impaired in ACS patients.
  • Oxidative stress and altered PON1 activities contribute to HDL dysfunction in ACS.
  • PON1 activity demonstrates a protective role against cardiovascular events in ACS.
Abstract

Keywords:
ACSCholesterol effluxHDLOxidative stressPON1

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