Related Experiment Video

Updated: Apr 23, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

26.7K

Reference values for leptin and adiponectin in children below the age of 10 based on the IDEFICS cohort

E Erhardt1, R Foraita2, I Pigeot3

  • 1Department of Paediatrics, University of Pécs, Pécs, Hungary.

International Journal of Obesity (2005)
|September 16, 2014
PubMed

Insights

This study established new reference values for serum leptin and adiponectin in normal-weight European children aged 3-9 years. These findings provide crucial data for interpreting hormone levels in pediatric health studies.

Area of Science:

  • Pediatric endocrinology
  • Human physiology
  • Nutritional science

Background:

  • Accurate reference values for serum leptin and adiponectin are essential for assessing metabolic health in children.
  • Previous studies have lacked comprehensive, age- and sex-specific data for prepubertal, normal-weight European children.

Purpose of the Study:

  • To establish age- and sex-specific reference values for serum leptin and adiponectin.
  • To provide normative data for normal-weight European children aged 3.0-8.9 years.

Main Methods:

  • Analysis of blood samples from 539 normal-weight children (aged 3.0-8.9 years) within the IDEFICS cohort.
  • Utilized the General Additive Model for Location Scale and Shape to derive age- and sex-specific percentiles.
  • Investigated the impact of obesity using sensitivity analyses with larger sample sizes.

Main Results:

  • Serum leptin levels showed a positive trend with age, while adiponectin levels showed a negative trend in both boys and girls.
  • Generally higher percentile values for both hormones were observed in girls compared to boys.
  • Specific ranges for the 97th percentile differences between sexes were quantified for adiponectin and leptin.

Conclusions:

  • This study presents the first known reference values for leptin and adiponectin in prepubertal, normal-weight children.
  • The developed reference curves facilitate a more precise interpretation of hormone levels in pediatric epidemiological and clinical research.
  • These findings contribute to a better understanding of hormonal profiles in healthy children.
Abstract

More Related Videos

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue10:28

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue

Published on: July 17, 2018

11.6K
Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

17.2K

Related Concept Videos

Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
998
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
543
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
394
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
1.3K
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
361