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Updated: Apr 23, 2026

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
Published on: March 30, 2019
Integrated bioinformatics analyses identify dysregulated miRNAs in lung cancer
1Department of Thoracic Surgery, Zhangjiagang First People's Hospital, Zhangjiagang, Jiangsu, China. zjgmcp@sina.com.
Background:
Lung cancer is the most common cause of cancer-related death worldwide. MicroRNAs (miRNAs) play important roles in various biological processes, including cell development, proliferation, differentiation and apoptosis.
Materials And Methods:
In the current study, using miRNA expression profiles from the Gene Expression Omnibus (GEO) database, we used three independent tests: Wilcox test, t-test and Fisher's exact test to investigate miRNA's involvement in lung carcinogenesis.
Results:
Ten differentially expressed miRNAs were identified. Among them, miR-675 drew specific attention. Ingenuity pathway analysis of its target genes revealed its impact on cell death and cell cycle. It is possible that miR-675 contributes to the pathogenesis of lung cancer through its down regulation of the tumor suppressor gene RB1.
Conclusions:
Our results suggest miR-675 may serve as a potential therapeutic target of lung cancer.
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