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Published on: October 12, 2012
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Current developments for the oral delivery of heparin
1Department of Pharmaceutical Technology, Institute of Pharmacy, Gerhard-Domagk-Straße 3, 53121 Bonn, Germany.
Current Pharmaceutical Biotechnology
|September 16, 2014
Summary
Developing oral heparin formulations remains crucial for improving patient compliance in anticoagulant therapy. This review explores strategies for effective oral unfractionated and low molecular weight heparins.
Area of Science:
- Pharmacology
- Drug Delivery Systems
- Biochemistry
Background:
- Anticoagulant therapy, including unfractionated heparin (UFH) and low molecular weight heparins (LMWH), is vital for treating and preventing thrombosis.
- Parenteral administration of UFH and LMWH limits patient compliance compared to oral medications.
- Existing oral anticoagulants have restricted indications, highlighting the need for oral heparin formulations.
Purpose of the Study:
- To review existing strategies for developing effective oral formulations of UFH and LMWH.
- To address the demand for improved oral anticoagulant options with established drugs.
Main Methods:
- Literature review of research strategies for oral heparin formulations.
- Analysis of approaches to achieve adequate anticoagulant effect via oral administration.
Main Results:
- Various strategies have been investigated to enable oral delivery of heparin.
- Challenges in oral bioavailability and efficacy of heparin formulations persist.
Conclusions:
- Developing oral heparin formulations is an ongoing area of research with significant clinical relevance.
- Successful oral heparin could enhance patient compliance and treatment options for thrombotic disorders.
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