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Related Experiment Videos

Activated suppressor cell function in severely disabled patients with multiple sclerosis.

J P Antel1, M S Freedman, S Brodovsky

  • 1Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.

Annals of Neurology
|February 1, 1989
PubMed
Summary

Suppressor cell function is not always defective in multiple sclerosis (MS) patients with severe progressive disability. Severely disabled MS patients showed increased suppressor cell levels, unlike those with moderate disability.

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Area of Science:

  • Immunology
  • Neurology

Background:

  • Defective suppressor cell function is linked to multiple sclerosis (MS) with progressive disease and moderate disability.
  • Previous studies suggest a role for suppressor cells in MS pathogenesis.

Purpose of the Study:

  • To investigate activated suppressor cell function in multiple sclerosis patients with severe progressive disability.
  • To compare suppressor cell function between severely disabled MS patients and those with moderate disability.

Main Methods:

  • Assessed activated suppressor cell function in two groups of MS patients: severe disability (Kurtzke score >= 6.5 for >= 2 years) and moderate disability (Kurtzke score <= 6.0 within 2 years).
  • Compared suppressor cell levels between patient groups and normal control subjects.

Main Results:

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  • Severely disabled MS patients exhibited significantly increased mean suppressor cell levels (59 +/- 8%) compared to moderately disabled MS patients (19 +/- 7%).
  • Moderately disabled MS patients showed significantly reduced suppressor cell levels compared to normal controls (47 +/- 4%).

Conclusions:

  • Suppressor cell function may not be defective in all multiple sclerosis patients with severe progressive disability.
  • Longitudinal studies are needed to determine if severely disabled MS patients previously had the suppressor defects observed in moderately disabled patients.