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Updated: Apr 23, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
Immunoglobulins in neonatal sepsis: has the final word been said?
Letizia Capasso1, Angela Carla Borrelli1, Teresa Ferrara1
1Section of Pediatrics, Universitá degli Studi di Napoli Federico II, Naples, Italy.
Abstract:
Systemic infection is a major cause of mortality and morbidity among premature neonates. In this fragile population, the immaturity of the innate immune response relates inversely to gestational age and is one of the determinants of susceptibility to infections. Antibiotic therapy, even when appropriately and timely instituted, may fail to prevent death or significant sequelae. The quest for additional strategies is still open; in this scenario, the supplementation with exogenous immunoglobulins represents an attractive additional strategy of defence. As current data are conflicting, we provide a critical appraisal with a focus on IgM enriched immunoglobulins preparations.
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