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Updated: Apr 23, 2026

Neuronavigation and Laparoscopy Guided Ventriculoperitoneal Shunt Insertion for the Treatment of Hydrocephalus
Published on: October 14, 2022
Cryptococcal ventriculoperitoneal shunt infection
Matthew J Viereck1, Nohra Chalouhi1, David I Krieger1
1Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA, USA.
Abstract:
The standard treatment of hydrocephalus is placement of a ventriculoperitoneal (VP) shunt. While infection is a common complication, rarely are fungal organisms implicated. Cryptococcus neoformans has been reported in only nine cases of shunt infection to our knowledge. The timing from shunt placement to symptom onset varies widely from 10 days to 15 months. We present a patient who developed a cryptococcal infection of his VP shunt more than two decades following shunt placement.
Insights
Late-onset fungal infections of ventriculoperitoneal (VP) shunts are rare. This case highlights a Cryptococcus neoformans VP shunt infection occurring over 20 years after placement, challenging typical timelines.
Area of Science:
- Neuroscience
- Infectious Diseases
- Medical Microbiology
Background:
- Ventriculoperitoneal (VP) shunts are standard treatment for hydrocephalus.
- Shunt infections are a known complication, but fungal infections are rare.
- Cryptococcus neoformans is an uncommon cause of VP shunt infection.
Observation:
- A patient developed a VP shunt infection.
- The causative organism was identified as Cryptococcus neoformans.
- Infection symptoms appeared over two decades after shunt placement.
Findings:
- This case represents a delayed-onset fungal VP shunt infection.
- Cryptococcus neoformans infection of a VP shunt occurred more than 20 years post-implantation.
- The typical timeframe for shunt infection symptom onset is significantly shorter.
Implications:
- Highlights the possibility of extremely late-onset fungal shunt infections.
- Suggests prolonged vigilance for shunt complications, even decades after placement.
- Underscores the need to consider rare pathogens in persistent or unusual shunt-related symptoms.
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