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Statins in oncological research: from experimental studies to clinical practice
Peter Kubatka1, Peter Kruzliak2, Vladimir Rotrekl3
1Department of Medical Biology, Jessenius Faculty of Medicine in Martin, Comenius University, Bratislava, Slovak Republic.
Critical Reviews in Oncology/Hematology
|September 16, 2014
Summary
Statins, cholesterol-lowering drugs, show promising anti-cancer effects by inhibiting tumor growth and spread. Further research supports their potential as anti-neoplastic agents, despite concerns about liver toxicity.
Area of Science:
- Oncology
- Pharmacology
Background:
- Statins are widely prescribed for dyslipidemia and elevated cholesterol.
- Emerging evidence suggests statins possess anti-tumor properties, impacting proliferation, apoptosis, angiogenesis, and metastasis.
Purpose of the Study:
- To review the mechanism of action, preclinical studies, and clinical efficacy of statins as anti-cancer agents.
- To discuss the potential role of statins in cancer treatment and their associated hepatotoxicity.
Main Methods:
- Review of epidemiological and preclinical studies on statins and cancer.
- Analysis of clinical efficacy data for statins in various cancer types.
- Discussion of statin mechanisms related to carcinogenesis.
- Examination of statin-induced hepatotoxicity.
Main Results:
- Statins exhibit anti-proliferative, pro-apoptotic, and anti-angiogenic effects.
- Promising efficacy observed in esophageal, colorectal cancers, and hepatocellular carcinoma.
- Statins' acceptable toxicity profile supports their development as anti-cancer drugs.
Conclusions:
- Statins demonstrate significant potential as anti-neoplastic agents.
- Further investigation into statins for cancer therapy is warranted, considering specific cancer types.
- Managing statin-induced hepatotoxicity is crucial for clinical application.
Keywords:
Anti-tumor propertiesCancer risk reductionCancer therapyCarcinogenesisChemopreventionStatinsMore Related Videos
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