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Updated: Apr 23, 2026
Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
Published on: November 29, 2024
Novel determinants preventing achievement of major cardiovascular targets in type 2 diabetes
Soumaïla Camara1, Evariste Bouenizabila2, Michel P Hermans3
1Ecole de Santé Publique, Faculté de Médecine, Université Libre de Bruxelles, Belgium.
Background:
T2DM management requires tight control of 3 critical quality indicators to prevent vascular complications: LDL-C, SBP, and HbA1c. This study evaluated the rate of T2DM patients attaining these critical quality indicators, and the pathophysiological or cardiometabolic traits predicting goal achievement.
Patients And Methods:
Cross-sectional analysis evaluating combined goal achievement (LDL-C<100 mg/dL; SBP<130 mmHg and HbA1c<7.0%) in 1005 T2DM outpatients (654 men) followed in a university hospital multidisciplinary department. Triple-goal achievers were compared to non-achievers regarding sociodemographics; anthropometrics; homeostatic model assessment (HOMA; β-cell function (B); insulin sensitivity (S); hyperbolic product (B×S)); CV and glucose-lowering drugs; micro-/macro-vascular outcomes; and 10-year UKPDS risk.
Results:
Eighty-eight patients (9%; ((3 targets) group) reached all goals, whereas 917 patients (91%; ((0-2 target(s)) group) missed 1, 2 or all 3 goals. Compared to (0-2 target(s)), (3 targets) had shorter diabetes duration; less familial diabetes history; lower waist/visceral fat; higher β-cell function and hyperbolic product (B×S); lower (B×S) loss rate and less metabolic syndrome (all p<0.05). They had lower apoB and triglycerides; and a 28% prevalence of atherogenic dyslipidemia (vs. 40% in (0-2 target(s)); p 0.0398). Microangiopathy (36% vs. 53%) and 10-year CAD risk (13% vs. 18%) were also significantly lower in (3 targets).
Conclusions:
The subset of T2DM patients achieving all critical quality indicators are characterized by a less severe cardiometabolic phenotype, while exhibiting a less pronounced alteration of their residual β-cell function. These differences are related to fewer microvascular outcomes and lower 10-year CV risk.
Insights
Achieving optimal diabetes control (LDL-C, SBP, HbA1c) is rare in T2DM patients. Those who meet all targets have better cardiometabolic health and fewer complications.
Area of Science:
- Endocrinology
- Cardiology
- Metabolic Diseases
Background:
- Type 2 Diabetes Mellitus (T2DM) management necessitates stringent control of LDL-C, SBP, and HbA1c to mitigate vascular complications.
- This study investigates the attainment rates of these critical quality indicators in T2DM patients and identifies predictive pathophysiological traits.
Purpose of the Study:
- To evaluate the proportion of T2DM patients achieving combined LDL-C, SBP, and HbA1c goals.
- To identify cardiometabolic factors associated with achieving these critical quality indicators.
Main Methods:
- Cross-sectional analysis of 1005 T2DM outpatients.
- Assessed combined goal achievement: LDL-C<100 mg/dL, SBP<130 mmHg, HbA1c<7.0%.
- Compared "triple-goal achievers" with "non-achievers" on various clinical and metabolic parameters.
Main Results:
- Only 9% of T2DM patients achieved all three critical quality indicators.
- Triple-goal achievers demonstrated shorter diabetes duration, lower visceral fat, better beta-cell function (HOMA B×S), and less metabolic syndrome.
- Achievers had lower apoB, triglycerides, atherogenic dyslipidemia, microangiopathy, and 10-year CAD risk.
Conclusions:
- T2DM patients achieving all critical quality indicators exhibit a less severe cardiometabolic phenotype.
- These patients show less pronounced alterations in beta-cell function.
- Attaining these goals is linked to reduced microvascular complications and lower cardiovascular risk.
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