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Updated: Apr 23, 2026

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
Published on: June 27, 2022
Design and characterization of 3-Azidothalidomide as a selective hydrogen sulfide probe
1Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia 23298.
Abstract:
Hydrogen sulfide (H2S) has been recently recognized as an important signaling molecule in biological systems. Herein, we report the development of a fluorescence turn-on probe based on the structure of pomalidomide, a FDA approved drug for the treatment of multiple myeloma. Various characterizations demonstrated high selectivity and sensitivity of this probe towards H2S. Furthermore, the application of this probe to detect H2S in living cells was confirmed by flow cytometry and fluorescence imaging studies.
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